However, induction of HnRNPK in response to DNA damage and ubiquitylation of HnRNPK mediated by wild-type HDM2 was not generally seen in any panel of cancer cell lines, suggesting that each E3 ligase could plausibly work in different cell and cell cycle phases or in a temporal or spatial specificity to provide timely control of HnRNPK stability. The gene discussed is MDM2; the disease is cancer.