SPOP has been shown to participate in diverse cellular processes and plays tumor suppressive and oncogenic roles in PrCa by targeting different substrates for ubiqutination-mediated proteolysis, including AR [19], steroid receptor coactivator 3 (SRC-3) [20], DEK, TRIM24 [21], BRD4 [22] and Nanog [23]. This evidence concerns the gene NCOA3 and neoplasm.