Furthermore, we found that PKMYT1 physically interacted with β-catenin proteins blocking the E3-ligase SCFβ-TrCP recognition, leading to stabilization of β-catenin proteins and constitutive activation of Wnt signaling, increased self-renewal ability of cancer stem cells in NSCLC (Fig. 10). This evidence concerns the gene PKMYT1 and non-small cell lung carcinoma.