NANOG and cancer: To further characterize the molecular mechanism by which PKMYT1AR/miR-485-5p/PKMYT1 axis regulates NSCLC progression, we performed the co-expression analysis and found that PKMYT1AR or PKMYT1 positively, whereas miR-485-5p negatively, correlates with the expressions of well defined cancer stem cell marker genes, including CD44, Sox2, Oct4, Nanog and ALDH1 (Fig. 6a-b and Fig. S6a) [11].