The results showed a weak negative correlation between the levels of IL-1β and Aβ1-42 in CSF of aMCI and AD patients (Fig. 5a, d), and a significant correlation between the IL-1β level and MMSE and MoCA scores (Fig. 5b, c, e, f), indicating that IL-1β, which associates with the progression of AD, may be a potential biomarker of neuroinflammation in AD patients. This evidence concerns the gene IL1B and Alzheimer disease.