These findings agreed with those of the heatmap, which showed that the levels of many genes involved in inflammasome-mediated inflammation, such as Il1r1, Il1rap, Nlrc4, Nlrp6, Nlrp9, Aim2, Casp1, and Casp4, were increased in PBMCs of AD patients (Fig. 1c). Here, CASP4 is linked to Alzheimer disease.