Among all subjects, circulating PTX3 level had a positive relation with the existence of PCOS (R = 0.363, P < 0.001), overweight/obesity (R = 0.171, P = 0.001), menstrual cycle length (R = 0.236, P < 0.001), basal LH to FSH ratio (R = 0.269, P < 0.001), TT (R = 0.524, P < 0.001), and serum E2 (R = 0.306, P < 0.001), as well as AFC (R = 0.244, P < 0.001). This evidence concerns the gene PTX3 and obesity due to melanocortin 4 receptor deficiency.