CRP and infection: Furthermore, Russo et al. [35] described that the 76% of septic arthritis were primary infections with a diagnosis based on one or a combination of clinical signs of infection, elevated serum C-reactive protein (CRP) and erythrocyte sedimentation rate ESR values, radiographic findings of bone resorption and/or loss of articular space, intra-operative purulence, and positive intra-operative and/or synovial fluid microbiology.