For example, exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma [25], macrophages derived exosomal miR-223 induced a chemoresistant phenotype of epithelial ovarian cancer cells through exosomal miR-223/PTEN-PI3K/AKT signaling pathway [26]. The gene discussed is PTEN; the disease is hepatocellular carcinoma.