In breast cancers, round and irregular shapes were 7.491 and 3.786 times more likely to express HER2+ than oval shapes, respectively; the presence of calcifications was 3.346 times more prone to express HER2+ than those without calcifications; and the presence of palpable ALN was 2.319 times more likely to express HER2+ than those without palpable ALN (Table 4). Here, ERBB2 is linked to calcification.