The number of participants receiving insulin or insulin along with OAD increased at 1 year with highest increase in the number of participants taking insulin with OAD was observed in the subgroup with diabetes for >10 years (OAD + insulin: baseline 690/1728 [39.9%] vs. 1 year 809/1667 [48.5%]) (Table S1). This evidence concerns the gene INS and diabetes mellitus.