We generated mice deficient for hepatic Rictor (LiRctrKO), a key component of mTORC2 (17), and injected them and their littermate controls with either empty vector (LiRctrKO+AAVcontrol) or WT Dyrk1b (LiRctrKO+Dyrk1bAAV-WT) and administered CD or HCD for 3 months. This evidence concerns the gene DYRK1B and heavy chain disease.