Accordingly, the levels of the DNL enzymes Fasn and Acc1 and p-PKCα/PKCα, a readout for mTORC2 activation (17), were increased in the liver of HCD- versus CD-fed mice (Figure 1, B and C) and positively correlated with degree of NASH severity (Supplemental Figure 1, D–F). Here, FASN is linked to metabolic dysfunction-associated steatohepatitis.