Differences in age, sex, TG, TC, ALT, TBil, hs‐CRP, the prevalence of hypertension, physical exercise, current smoker, family income, liver cirrhosis, fatty liver, gallstone disease and gallbladder polyp were found between HBsAg seropositive group and HBsAg seronegative group (P < .05). This evidence concerns the gene CRP and fatty liver disease.