IDH2 and central nervous system cancer: Low grade glioma has a higher incidence of IDH 1 compared with IDH2 mutations, of which the IDH R132H mutation dominates (R132H (CAT) 92.7%, R132C (TGT) 3.6%, R132S (AGT) 1.8%, R132G (GGT) 0.9%, R132L (CTT) 0.9%, R132V (GTT) 0.5%) [30].