Therefore, with sarcopenia, some of the alterations of the ECS might be differently orchestrated in oxidative and glycolytic skeletal muscles: On the one hand, the reduced OEA levels observed in the EDL could result in a reduced TRPV1 and PPARα activity leading to an impairment of mitochondrial biogenesis and function and of skeletal muscle regeneration. This evidence concerns the gene PPARA and sarcopenia.