CD274 and neoplasm: There are three main phenotypes associated with PD‐(L)1 resistance: a TME lacking lymphocytes (‘immune desert’), a TME in which lymphocytes are physically excluded from tumor cells (‘immune‐excluded’), and a TME in which lymphocytes infiltrate the tumor tissue (‘inflamed’) but are inactivated through a negative feedback loop of PD‐L1 signaling, resulting in T‐cell ‘exhaustion’ [80, 81].