CCN2 mRNA levels in the infarcted region increased rapidly following onset of ischemia and remained high during all the phases of wound healing, i.e. the inflammatory phase (day 2 post-MI), the proliferative phase (day 7 post-MI; granulation tissue) and maturation phase (day 50 post-MI; differentiated scar tissue) (Fig. 1a). The gene discussed is CCN2; the disease is ischemia.