This cellular distribution is very similar to that previously observed for CCN2 and other 4-domain CCN proteins during formation of granulation tissue following myocardial necrosis (Ahmed et al. 2004; Colston et al. 2007; Jun et al. 2015) and may point to a role of CCN5 in inhibiting the other 4-domain CCN proteins. This evidence concerns the gene CCN5 and necrosis.