The promoter region of the CCN5 gene has previously been reported to contain a putative glucocorticoid response (enhancer) element (GRE) (5′-GGTACGTACTGTTCC-3′) and to respond to glucocorticoid stimulation (dexamethasone) in estrogen receptor alpha (ERα)-negative MDA-MB-231 breast cancer cells (Ferrand et al. 2012). Here, ESR1 is linked to breast cancer.