IRS2 and type 2 diabetes mellitus: A study confirmed that the C allele increased the risk of type 2 diabetes in a Chinese Han population, replicating the association of KCNQ1 rs2237892 with T2DM susceptibility, and their study also indicated that genotype CC tended to be associated with an increased risk of hypertension and macrovascular complications in patients with T2DM [1], and Zhou et al. presented new data suggesting that KCNQ1 polymorphisms affect T2DM risk by regulating the IRS-2/PI(3)K/Akt signaling pathway [12].