In conclusion, our investigation cannot prove the association of KCNQ1 rs2237892SNP with T2DM in Asian populations, and the observation of the C allele as a risk allele for T2DM in non-Asian populations may be due to small sample sizes [16, 17], taking into account that geographical or cultural barriers increase the genetic distance, functional genes or regulatory regions may be disturbed by independent sets of rare mutations, and different patterns of linkage disequilibrium may also be an influencing factor. Here, KCNQ1 is linked to type 2 diabetes mellitus.