INS and type 2 diabetes mellitus: The selective inhibitor chromanol 293B inhibited KCNQ1 potassium channel activity and significantly increased insulin secretion [5]; Yazdi et al. demonstrated a significant association between KCNQ1 and T2DM [6], but, research showed there was no significant association between KCNQ1 and T2DM [7]; Liu et al. and Yu et al. performed meta-analysis of multiple loci in the KCNQ1 gene, and the results again demonstrated the association between KCNQ1 and T2DM [8, 9], but these two papers introduced data from meta-analyses, respectively, and their strength of proof may be weakened.