The level of white blood cells, hemoglobin, platelets, albumin, prealbumin, and cholinesterase in patients with cirrhosis was significantly lower than those in patients with chronic hepatitis B and healthy controls (P < 0.01, respectively), and the level of aspartate transferase, total bilirubin, prothrombin time, and INR was significantly higher than those in the chronic hepatitis B group and the healthy control group (P < 0.01, respectively). The gene discussed is F2; the disease is chronic hepatitis B virus infection.