For example, when Itchy E3 ubiquitin protein ligase (ITCH) was increased in non-small cell lung cancer (NSCLC) cells by has_circ_0043256, it was observed to induce apoptosis, while an increase of ERBB2 in the nucleus pulposus (NP) cell by circGRB10 was reported to inhibit apoptosis.48 The gene discussed is ITCH; the disease is non-small cell lung carcinoma.