For example, when Itchy E3 ubiquitin protein ligase (ITCH) was increased in non-small cell lung cancer (NSCLC) cells by has_circ_0043256, it was observed to induce apoptosis, while an increase of ERBB2 in the nucleus pulposus (NP) cell by circGRB10 was reported to inhibit apoptosis.48 This evidence concerns the gene ERBB2 and non-small cell lung carcinoma.