To investigate the specific role of tubular LincRNA-p21 in diet-induced obesity (DIO) and associated metabolic disorders, tubule-specific LincRNA-p21 knockout (KO) mice and their control (CTL) littermates were generated (Figure S1) and fed normal diet (ND) or HFD for 8 weeks before sacrifice (Figure 1C). This evidence concerns the gene CDKN1A and obesity due to melanocortin 4 receptor deficiency.