We and others observed the potential of LincRNA-p21 to mediate p53 activity in a feedback manner,30,39 as well as the capacity of p53 in perturbing multiple biological processes under metabolic stress; however, we cannot exclude the possibility of LincRNA-p21 as an effective upstream regulator of p53 to regulate its function under lipotoxic kidney injury. The gene discussed is TP53; the disease is kidney injury.