Emerging evidence indicates that tubules may also contribute to glomerulopathy by secreting paracrine factors like nicotinamide mononucleotide and vascular endothelial growth factor (VEGF) that could diffuse back to the glomerulus to induce podocyte effacement, mesangial proliferation, and glomerular endothelial dysfunction in DKD.37 Here, VEGFA is linked to lipoprotein glomerulopathy.