Additionally, the data from western blot assay also demonstrated that the protein level of Bcl-2 was increased while that of Cleaved Caspase-3 and Cleaved Caspase-9 was decreased in circ_PTN-overexpressed GBM cells treated with 1.5 μM DDP (Figure 3G). This evidence concerns the gene CASP3 and glioblastoma.