As expected, the luciferase activity was significantly decreased in DDP-resistant GBM cells co-transfected with PIK3R3 3′UTR-Wt and miR-542-3p mimics while no statistical significance of that was observed in DDP-resistant GBM cells co-transfected with PIK3R3 3′UTR-Mut and miR-542-3p mimics (Figure 5D). This evidence concerns the gene PIK3R3 and glioblastoma.