CD274 and breast cancer: We performed the immunophenotyping analysis of HDN and LDN in both metastatic and non-metastatic BC patients (Supplementary Figure 3) and observed that the percentage of PD-L1 is increased in HDN (p < 0.05, Supplementary Figure 3A) and in LDN (p < 0.01, Supplementary Figure 3C) of metastatic patients when compared to non-metastatic.