Similarly, ERK1/2 inhibition attenuated CCL20-dependent CCL20 mRNA and CCL20 protein production by the colorectal cancer cells to the degree seen with HGF blockade (4.5 fold for CCL20 versus 1.9 fold for CCL20 with ERK1/2 inhibitor and 1.6 for CCL20 with anti-HGF antibody in HT-29, 2.7 fold versus 1.2 fold and 1.5 fold in HCT16, Figure 5B, Supplementary Figure 5). Here, MAPK3 is linked to colorectal cancer.