CCR6 and colorectal cancer: While the effects of CCL20-CCR6 interactions in colorectal cancer have largely been thought to be mediated by stromal elements such as macrophages [8, 9]; regulatory T cells (Tregs) [7, 11]; B cells and γδ T cells [10]; and blood vessels [2], several studies have also demonstrated the importance of direct effects on neoplastic epithelial cells.