CASP3 and neoplasm: Moreover, we further verified that overexpression of circ_0013401 markedly upregulated the levels of PAK2, p62, and Bcl-2 expression and downregulated LC3B II/I, Beclin1, Bax, and cleaved caspase-3 expression in mouse tumor tissues; knockdown of circ_0013401 produced the opposite effects on the expression of all these proteins in mouse tumor tissues (Figure 10(e)).