JWJGC inhibited the proliferation of RA-FLS by downregulating the expression of NLRP3, ASC, caspase-1/3/4/5, and GSDMD, reducing the secretion of IL-1β and IL-8, repressing the activity of LDH, and decreasing the double-positive FITC anticaspase-1 and PI. This evidence concerns the gene CASP1 and rheumatoid arthritis.