Furthermore, the western blot results suggested that inhibition of GTF2E2 indeed downregulated the level of mesenchymal markers including N-cadherin, β-catenin, Snail, and Vimentin, and upregulated the level of epithelial marker E-cadherin in ESCC cells. The gene discussed is GTF2E2; the disease is esophageal squamous cell carcinoma.