PRKDC and osteosarcoma: DNA-PK is one of the central constituents of DDR, and its inhibition was shown to radiosensitize NSCLC cell lines (NU7441 at 0.3 μM)26, or human osteosarcoma cells (KU60648, 0.3 μM)27 to X-ray radiation as well as to carbon ion exposure (M3814 at 0.1–1 μM)24.