These findings, together with the observation the TRPM8 modulators inhibit the proliferation of AR-expressing castrate resistant prostate cancer (CRPC) cells, while leaving unaffected the behavior of AR-negative PC cells, offer new insights into the knowledge of TRPM8 in PC pathogenesis and pave the way for novel promising strategies in clinical management of PC patients. This evidence concerns the gene AR and pachyonychia congenita.