We recently found that SAMP1/TA-1 mice dosed repeatedly with lipopolysaccharide (LPS) exhibit HLH-like features such as severe pancytopenia, hepatomegaly, splenomegaly, hypofibrinogenemia, hyperferritinemia, and hemophagocytosis in peripheral blood, BM, and spleen; thus, they serve as a useful model of sHLH20. This evidence concerns the gene TMEM201 and hemophagocytic syndrome.