Notably, the interaction between AMD-predisposing alleles NPLOC4-TSPAN10 (rs6565597.T) and CFH (rs10922109.C) significantly increased the average thickness of the INL-ELM (Fig. 3) (beta = 0.25; p = 0.0004). This evidence concerns the gene NPLOC4 and age-related macular degeneration.