Conversely, we also found that the interaction between AMD-predisposing rs6565597 T allele (NPLOC4-TSPAN10) and the rs61985136 T allele (RAD51B) was nominally associated with a decreased central thickness of the ISOS-RPE layer, however, this was not significant after Bonferroni correction (beta = − 0.23, p = 0.0009, Bonferroni-adjusted p = 0.15). This evidence concerns the gene RAD51B and age-related macular degeneration.