The strongest locus in proximity to EXOC5 (rs76684157, p = 9.1 × 10−10) was associated at a trend level with the medication nicorandil, a vasodilatory drug and anti-anginal agent, being taken by the UK Biobank participants (p = 1.8 × 10−4), while the locus close to TSHZ1 (rs4891262, p = 7.4 × 10−10) was associated at a trend level with the medication spironolactone, given to treat high blood pressure and heart failure (p = 2 × 10−4). This evidence concerns the gene EXOC5 and hypertensive disorder.