Three genetic findings were related to the GM volume measured in the cerebellum of the ~ 10,000 UK Biobank participants: SLC39A8/ZIP8 which has been linked to higher risk of cardiovascular death18,19, SLC44A5 an important gene for metabolism of lipids and lipoproteins20, and PAPPA, which critically codes for a protein that acts in particular as a predictor of poor outcome in transient ischemic attack and ischemic stroke21. The gene discussed is PAPPA; the disease is transient ischemic attack.