In order to ask whether the phosphorylated SYK is involved in the progress of liver fibrosis, we collected fibrotic liver tissues of patients with Ishak classification as the clinicopathological standard and found that p-SYK expressed in different Ishak Graded fibrotic livers were all up-regulated and positively correlated with the severity of fibrosis (Fig. 1A). Here, SYK is linked to Hepatic fibrosis.