Moreover, silencing of FBXW7 inhibited polyubiquitination of ZFP36, increased ZFP36 protein expression, and reduced VEGF-C expression in OTUD3-silencing esophageal cancer cells (Supplementary Fig. 5g–i), suggesting that downregulation of FBXW7 rescues the effects of OTUD3 depletion in ZFP36 and VEGF-C expression. Here, OTUD3 is linked to esophageal cancer.