After the consumption of a regular diet, mice with chronic elevation of GP73 in hepatocytes recapitulated almost all of the characteristic features of obese NAFLD, including reduced body weight, decreased plasma lipid levels, massive intrahepatic lipid accumulation, elevated baseline levels of inflammatory cytokines, and gradual insulin resistance development3,4. This evidence concerns the gene GOLM1 and metabolic dysfunction-associated steatotic liver disease.