To inhibit the non-canonical activation of NF-κB, prednisolone downregulates NF-κB subunits such as RELB, and other proteins related to NF-κB activation such as MAP3K14 (NF-κB-inducing kinase, NIK) in both EGFRwt and EGFR mutant NSCLC cell lines at an mRNA and protein level (Fig. 1r–w). Here, RELB is linked to non-small cell lung carcinoma.