CD274 and neoplasm: Strikingly, when the predictive power of pPD-L1Adj. was compared to conventional histological PD-L1 quantification (TPS > 50% and ≥1% in tumor biopsies), pPD-L1Adj. was found to much better predict therapy response towards ICI (Fig. 7o, Supplementary Fig. 12k, l).