DROSHA and cancer: Remarkably, analysis of TCGA datasets revealed that expression of these miRNA biogenesis (DICER1, XPO5, and DROSHA) and targeting (AGO2, PPP6C, and ANKRD52) machinery components all positively correlated with the intratumoral T cell abundance across almost all human cancer types, while SOCS1 expression did not exhibit such correlation (Fig. 7g).