Presentation of the SIINFEKL epitope from OVA in the context of H2Kb was also significantly lower in IFNγ-stimulated ANKRD52-deficient cells than control cells (Fig. 4i; Supplementary Fig. 9g, h), suggesting that loss of ANKRD52 decreased the levels of antigen-loaded MHC-I on the surface of tumor cells and thus compromised their recognition by T cells. The gene discussed is IFNG; the disease is neoplasm.