SOCS1 and colorectal carcinoma: Gene set enrichment analysis (GSEA) of MC38 transcriptome identified 19 IFNγ signaling genes significantly upregulated in ANKRD52-deficient cells compared to control cells (Fig. 6b; Supplementary Fig. 10b; Supplementary Data 3), among which SOCS1 was also shown to be similarly controlled by ANKRD52 in human colorectal carcinoma HCT116 cells21 (Supplementary Fig. 10c).