Consistently, elevation of KCNK15-AS1 resulted in increased expression of epithelial marker (E-cadherin) and lowered level of mesenchymal marker (N-cadherin) (Fig. 2B, C), indicating that KCNK15-AS1 impeded EMT process of PC cells. The gene discussed is KCNK15; the disease is pachyonychia congenita.