TNF and neoplasm: Although mice treated with T3/28 CAR-T cells showed moderately higher levels of IL-2, IL-8, and TNF-α compared with the 19BBz CAR-T cell group, no significant changes were found in other cytokines (online supplemental figure S7B), suggesting that T3/28 CAR-T cells promote tumor control (figure 4) in tumor-bearing B-NDG mice without causing detectable organ toxicity.