KLK3 and prostate cancer: We observed fewer men with prostate cancer and proportionally more advanced prostate cancer diagnosed in 2013 to 2017 than in preceding years for both racial groups, but adjustment for a period effect of year of diagnosis 2004 to 2012 versus 2013 to 2017 did not result in changes in Black-NHW odds ratio estimates for PSA, GS, stage or prostate cancer risk of more than 1% (Supplementary Table S5).