To further examine intersecting social factors that may impact prostate cancer risk profile, we conducted a population-based study using California Cancer Registry (CCR) data of Black men and NHW men in California with prostate cancer from 2004 to 2017 with detailed information on PSA, GS, and stage, in addition to information on individual characteristics (age at and year of diagnosis, marital status, insurance status) and nSES. This evidence concerns the gene KLK3 and prostate cancer.