In breast cancer, CAFs-derived exosomes carrying miR-181d-5p can promote proliferation, invasion, migration, and EMT and inhibit apoptosis of cancer cells by targeting caudal-related homeobox 2 (CDX2) and then downregulating CDX2 and its downstream gene -homeobox A5 (HOXA5) [129]. The gene discussed is HOXA5; the disease is breast carcinoma.