In breast cancer, the CAFs-derived exosomal small nucleolar RNA host gene 3 (SNHG3), which is a lncRNA that acts as a molecular sponge of miR-330-5p to up-regulate pyruvate kinase M1/M2 (PKM) expression, can lead the inhibition of mitochondrial oxidative phosphorylation and enhanced breast tumor cell proliferation [130]. The gene discussed is SNHG3; the disease is breast cancer.