Interestingly, the finding that in renal cell carcinoma, obesity is associated with a diminished efficacy of PD-1 blockade, has been ascribed, at least in part, to the presence of constitutively elevated IL-1β levels which can also frequently found in the microenvironment of cHL [21, 22]. This evidence concerns the gene PDCD1 and obesity due to melanocortin 4 receptor deficiency.