We also found that BUB1 was positively related to STAT3 based on TCGA data in the online GEPIA database (R = 0.21; P < 0.05; Fig. 2D), which further supports the hypothesis that BUB1 might regulate the progression and prognosis of bladder cancer by mediating the STAT3 signaling pathway. The gene discussed is STAT3; the disease is urinary bladder cancer.