HCAR3 and breast cancer: However, HCAR3 knock-down effects have not been assessed in luminal A BC cell lines, which is the molecular subtype reported in the two BC-affected individuals from the AHCC with HCAR3 BC-associated variants, HCAR3 c.560G > A (p.R187Q) and HCAR3 c.1117delC (p.Q373Kfs*82).