HCAR2 and breast cancer: Interestingly, most of the detected HCAR2 missense variants were predicted to be benign, including the three BC-associated missense variants, HCAR2 c.424C > T (p.R142W), HCAR2 c.517_518delinsAC (p.G173T), and HCAR2 c.1036A > G (p.M346V).