During AD and other tauopathies, tau aggregates in the somatodendritic compartment of neurons in selected brain regions, where it forms neurofibrillary tangles (NFTs) [24 The redistribution of tau from the axon to the somatodendritic compartment is associated with increased tau phosphorylation [25-28 Tau is also subject to several other post-translational modifications such as O-glycosylation, ubiquitination, nitration, and truncation, all of which can contribute to the pathological changes in tau localization and function [29. Here, MAPT is linked to Alzheimer disease.