We found that many terms were related to the malignant characteristics of tumor cells in the GO analysis, and the most significantly altered pathways in the KEGG analysis, such as the ‘Hippo signaling pathway’, ‘PI3K-Akt signaling pathway’, ‘pathways in cancer’, and ‘ECM-receptor interaction’, were related to tumor angiogenesis, invasion, migration, changes in the microenvironment, etc [42,56,57]., suggesting that the upregulated circRNAs may be involved in the pathogenesis and progression of MM. The gene discussed is AKT1; the disease is cancer.