For example, miR-145-3p was found to be closely related to PCa and to be a target of metadherin (MTDH) [19], miR-145-3p may regulate the expression of hsa_circRNA_008068 and hsa_circRNA_406557 in LNCaP cells [17], and miR-145-5p and miR-145-3p were downregulated in CRPC [20]. Here, MTDH is linked to posterior cortical atrophy.