EDN1 and coronary artery disorder: A previous study in a Japanese population reported an association between MRTFA and a higher risk of CAD as well as with the severity of CAD.109 In mouse models, MRTFA was reported to be associated with the accumulation of proatherogenic macrophages in atherosclerotic plaques.110 Endothelin receptor type A (EDNRA), expressed in smooth muscle cells, encodes a receptor for endothelin-1, the most potent endogenous vasoconstrictive peptide.