Numerous studies have found binding of endothelin-1 to the receptor promotes cell proliferation contributing to atherosclerosis.111 eQTL (expression quantitative trait loci) analyses in the current study prioritized other vascular molecules related to vascular tone regulation, Rho GTPase-activating protein 42 (ARHGAP42) and ARHGAP26 (closest gene of fine-mapped variant at chromosome 5), although its link to atherosclerosis is unclear.112. The gene discussed is EDN1; the disease is atherosclerosis.