EDNRA and peripheral arterial disease: The shared genetic background was evident from overlaps of loci between the current GWAS and previous GWAS on CVD/risk factors as listed in GWAS Catalog.34 Studies reported association of APOB with CAD,35 pulse pressure,36 LDL-C,37–43 and total cholesterol.42,44ADAMTS9 has been implicated in previous GWAS of CAD,35 DBP, SBP32,45 as well as total cholesterol level.43 Association with CAD,35,46,47 ischemic large artery stroke,31,46 intracranial aneurysm,48 PAD,49 pulse pressure,32,50,51 and SBP32,52 were previously reported for endothelin receptor gene EDNRA.