A number of Wnt pathway related genes were upregulated or downregulated in radiotherapy treated glioma patients from the TCGA database, such as LGR6, SERPINF1, RAC2, FOSL1, CCN4, PLCB2, JUN, WNT5A, TCF7, FZD2, FZD6, MMP7, ROR2, CXXC4 and SFRP1 (S1 Table). Here, LGR6 is linked to central nervous system cancer.