A number of Wnt pathway related genes were upregulated or downregulated in radiotherapy treated glioma patients from the TCGA database, such as LGR6, SERPINF1, RAC2, FOSL1, CCN4, PLCB2, JUN, WNT5A, TCF7, FZD2, FZD6, MMP7, ROR2, CXXC4 and SFRP1 (S1 Table). This evidence concerns the gene CCN4 and central nervous system cancer.