A number of Wnt pathway related genes were upregulated or downregulated in radiotherapy treated glioma patients from the TCGA database, such as LGR6, SERPINF1, RAC2, FOSL1, CCN4, PLCB2, JUN, WNT5A, TCF7, FZD2, FZD6, MMP7, ROR2, CXXC4 and SFRP1 (S1 Table). The gene discussed is SERPINF1; the disease is central nervous system cancer.