CCN4 and central nervous system cancer: Our data indicated that the Wnt pathway activation related genes such as CCN4, FOSL1, LGR6, MMP7, RAC2, SERPINF1 and TCF7 were upregulated, while Wnt pathway inactivation related gene such as CXXC4 was downregulated in radiotherapy treated glioma patients from TCGA database (Fig 4A).