In addition to the role of IGF-1 in the pathophysiology of CAD, its role in glucose metabolism and homeostasis also deserves further attention .15,16 Previous studies have demonstrated that hyperglycemic patients have significantly lower levels of IGF-1 compared with normal subjects .17,18 As hyperglycemia on hospital admission has been linked to increased risk of subsequent cardiovascular mortality and morbidity among ACS patients,1,17 investigating the role of IGF-1 in hyperglycemic ACS patients might be of particular interest. The gene discussed is IGF1; the disease is Hyperglycemia.