IGHE and asthma: Interestingly, nasal AECs isolated from subjects with asthma (Severe Asthma Research Program 3 cohort) carrying CC allele expressed less SPLUNC1, which negatively correlated with the severity of the disease (asthma endpoints such as FEV%, fractional exhaled nitric oxide, and serum IgE) as compared with CT and TT genotypes (73).