Recently, high throughput genetic technologies such as whole exome sequencing, next generation sequencing, and bioinformatics analysis implicated mutations in FAM20A (FAMily with sequence similarity 20A) as the defective gene in ‘‘Amelogenesis Imperfecta and Gingival Fibromatosis Syndrome’’ (AIGFS; OMIM 614253). The gene discussed is FAM20A; the disease is amelogenesis imperfecta type 1G.